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I generally use TweetDeck because I really like the interface but here is one that you should try by Loic Le Meur.  He has just released a NEW version of Twhirl and so far, I like it.  In fact, I like it a lot. 

So what is twhirl?

twhirl is a social software desktop client, based on the Adobe AIR platform.

Some of twhirl’s features:

• runs on both Windows (2000/XP/Vista) and Mac OSX
• connects to multiple Twitter, laconi.ca, Friendfeed and Seesmic accounts
• displays notifications for new messages
• shorten long URLs (using bit.ly, snurl, twurl or is.gd)
• cross-post your updates to Jaiku and many other sites like Facebook, MySpace, LinkedIn and more via Ping.fm
• post images to TwitPic
• search tweets using Twitter Search and TweetScan, and follow topics in near-real time with saved searches
• automatically find tweets mentinoning your @username
• record a video on Seesmic, and share it on twitter immediately
• get your seesmic updates in real-time using XMPP
• English spell checking

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Jack Cook (2693 Posts) - Website | Twitter | Facebook