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That is how to do it, but he asked how does he know it's ok :)
Some are obvious by the name. For example, I run SKSchema, well there is something like that in the StartUp folder. Guess what will happen if I delete it? SKSchema will not do all I want it to.
Normally you can do some searching (using Google or this board) for each item. Somewhere out there each is probably listed with its "owner" and if it is safe to remove.
Perhaps you could list what you see?
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