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I dont 'see fragmentation being an issue considering that almost everyone is using solid state storage. with "RAM" all areas of memory can be accessed in the same timeframe (hence the 'random' terminology in RAM), which differs from a platter on a disk where the read arm has seek to various points in order to retrieve the data, accounting for longer read times when data is not placed in consecutive sectors.
however, for those who are using microdrives, defragging could certainly help.
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