Put me down as having the same issue. x50v w/ WM5 and AS4.1
I can sync fine with Bluetooth, but no USB. I am using Sygate Personal Firewall, and have added the AS .exes to the allow list. Still no go.
Doesn't MS realize that you cannot call something an "upgrade" if you take away functionality.
Very frustrated

...but too stubborn to go back to WM2003SE