Sorry a useless righty here :D From what I've found looking around the board, there's not much you can with msft's software... here's a silly thread, but they did touch on this topic:
http://www.aximsite.com/boards/showt...ight=left+hand
I tried to search with google for you, and didn't come up with much. I know several of my apps offer a lefty option, but I've never seen anything with the o/s. That's really an oversight, as lefties are what, 15% of the population?
Microsoft, get with it!