New axim user, tried 4.2 and 4.1. Problems:
1. File->Connection Settings never opened another window.
2. Close AS once, it will never open again until reboot.
3. USB syncing spotty, sometimes works, sometimes not.
4. No ability to have AS listen for BT port (see #1)

4.5 fixed these problems for me. Syncing with whatever version of outlook came on the disk seems to still work, at least the calendar and contacts which is all I use, can't say about email. I can USB and BT sync no problem.

Maybe this will help others.