Ok, if two fail to start, it's not likely to a failed card. So, help us here with some symptoms. Exactly what is the message for failure and what software is reporting it? Are there lights on the card? What are they doing? What does the manual say they should do? Most GPS units don't start until they are accessed appropriately. Also, only one application can use the COM port at a time, so make sure you do kill anything that uses COM4 and after you use a GPS application, make sure you kill that one before you start another.
The First GPS is a pretty old chipset. I've seen references to it from 2000. It may be very slow to start and very slow to the first fix. Which of these is the one you are using?
http://www.f-tech.com.tw/Eng/Right_gps_all.htm