I have no screen cover so that isn't it. I tried cleaning the sides as suggested but to no avail. If I reset the Axim with the reset button on the back, the reboot process asks to touch the screen in any position to start the alignment process. The first alignment touch works. The second one doesn't. So after rebooting I touched the screen in the approximate location of the second touch and that gets the alignment process started. I really doubt this is a problem with the touch screen but rather the alignment software is hanging up. Is there a way to reload this portion of the software?