I am experiencing an issue with my screen.
About 75% of the times I soft-reset my Axim, a single pixel goes out. It will be out from then to some random time. I have tried soft-reset and hard-reset, but neither seem to fix it at the time. Then I will notice later it is working.
It seems to be the same pixel each time.

Is this typical or does this indicate a problem I should be concerned about?

So far it is annoying - I want my baby to be perfect.

I would say it is a defect and would suggest you get it replaced before you find yourself with more pixels missing. If you ever want to upgrade in the future to another axim its pretty hard to sell a defective one