I use the mouse/keyboard setup and that really isn't the problem. Wireless, mouse and keyboard function together, with out a hitch. The mouse is sensitive to the surface it is on, that's the only issue. It is the wireless connection that seems to be the problem.
I too, have had to change channels at both the office and home. The office shows 8 or 9 active wireless ssids. urgh! (I just looked and 14 networks are showing up on WIFOFUM -- Seems like we should all get together and make a stronger, more secure setup, but I guess that would be another thread.) Most are on Channel 6, a few are channel 1. I have changed mine to channel 11. It seems to be fairly stable, although the signal is not particularly strong. Lots of walls with lots of metal bookcases.
But, microwave usage causes problems every time. At the office it is not too bad, I'm using a buffalo access point. At home, I'm using a netgear WGU624.

I don't really nead all the features and they seem to get in the way when using in a mixed mode setup - airport on a mac, one dell cabable of an 801a connection, and the ax with the 801 b connection, as well as several wired computers. Again the killer is the microwave. Using the microwave while connected totally messes up the connection. but now that I know, it's a lot easier to keep up and running most of the time.