The file that I attached in this thread:
http://www.aximsite.com/boards/showthread.php?t=92000
is an example of a program hack.
You place it in the same directory as the program you're trying to hack and rename it match the program's executable.
In this case it was for Pocket Word (pword.exe.0409.mui).
To use it for an other program, like calculator.exe, you'd rename it to calculator.exe.0409.mui.
The 0409 refers to the language of your operating system and 0409 is for English.
The same file should work for all programs and all operating systems if it's renamed correctly.
If the program is already VGA-aware it should have no effect.
I say 'should' because Pocket Word is supposedly already VGA-aware yet the problem described in that thread is somehow cured by the hack.
If the program isn't VGA-aware then you should see the difference but again it is a program hack and not an operating system hack so all toolbars, scrollbars, etc. will be unaffected.
Stand-alone programs like Tweaks2k2 and ForceHires.exe use a similar procedure but behind the scenes where you never notice it.
You tell it which programs to hack and it does it.
An other method is to use a binary editor to actually edit the programs executable and make it VGA-aware.
ResHacker.exe is probably the most common for this and you can search for instructions.
This won't work for files in ROM that you can't access (like pword.exe) but for those that you can access it saves you from having multiple .MUI files taking up RAM space and once done, the change is permanent (until you re-edit it).
Operating system hacks are programs like SE_VGA or OZ_VGA that resize everything.
http://www.aximsite.com/boards/showthread.php?t=67899
These are probably what you want because while utilizing all pixels they still let you adjust the sizes of individual fonts and OS elements like tool and scroll bars.